InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP2

Summary

InnateDB Protein

IDBP-79796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP2

Protein Name

microtubule-associated protein 2

Synonyms

MAP2A; MAP2B; MAP2C;

Species

Homo sapiens

Ensembl Protein

ENSP00000353508

InnateDB Gene

IDBG-79788 (MAP2)

Protein Structure

UniProt Annotation

Function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03175, ECO:0000269PubMed:21537465}. Note=About 30% of expressed METAP2 associates with polysomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	47 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding

Biological Process

GO:0001578	microtubule bundle formation
GO:0007409	axonogenesis
GO:0016358	dendrite development
GO:0021954	central nervous system neuron development
GO:0031175	neuron projection development
GO:0048813	dendrite morphogenesis
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0034399	nuclear periphery
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0044297	cell body