InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF6B

Summary

InnateDB Protein

IDBP-79923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF6B

Protein Name

activating transcription factor 6 beta

Synonyms

CREB-RP; CREBL1; G13;

Species

Homo sapiens

Ensembl Protein

ENSP00000364349

InnateDB Gene

IDBG-239314 (ATF6B)

Protein Structure

UniProt Annotation

Function

Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein.Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006986	response to unfolded protein
GO:0007165	signal transduction