InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZMIZ1

Summary

InnateDB Protein

IDBP-79984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZMIZ1

Protein Name

zinc finger, MIZ-type containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334474

InnateDB Gene

IDBG-79982 (ZMIZ1)

Protein Structure

UniProt Annotation

Function

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:14609956}. Cytoplasm {ECO:0000269PubMed:14609956}.

Disease Associations

Tissue Specificity

Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:14609956}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding

Biological Process

GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0003007	heart morphogenesis
GO:0006351	transcription, DNA-templated
GO:0007296	vitellogenesis
GO:0007569	cell aging
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048589	developmental growth
GO:0048844	artery morphogenesis