InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FKBPL

Summary

InnateDB Protein

IDBP-80272.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FKBPL

Protein Name

FK506 binding protein like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000364298

InnateDB Gene

IDBG-80270 (FKBPL)

Protein Structure

UniProt Annotation

Function

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21. {ECO:0000269PubMed:15664193}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed with higher levels in testis. {ECO:0000269PubMed:15664193}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0009314	response to radiation
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UIM3