Version 5.4
Homo sapiens Protein: TMSB15A
Summary
InnateDB Protein IDBP-80275.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMSB15A
Protein Name thymosin beta 15a
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000289373
InnateDB Gene IDBG-80273 (TMSB15A)
Protein Structure
UniProt Annotation
Function Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Neuroblastoma-specific. {ECO:0000269PubMed:9039501}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0030036 actin cytoskeleton organization
GO:0042989 sequestering of actin monomers
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001152 Thymosin beta-4
IPR016323 Thymosin beta-4, metazoa
PFAM PF01290
PRINTS
PIRSF PIRSF001828
SMART SM00152
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0CG34
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 286527
UniGene
RefSeq NP_068832
HUGO HGNC:30744
OMIM 601587
CCDS CCDS14498
HPRD 06744
IMGT
EMBL AK291479 AK311771 AL035609 BC000183 CH471190 D82345 Z70227
GenPept AAH00183 BAA11556 BAF84168 BAG34714 CAC18959 EAW54739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca