Version 5.4
Homo sapiens Protein: BEX1
Summary
InnateDB Protein IDBP-80368.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BEX1
Protein Name brain expressed, X-linked 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361813
InnateDB Gene IDBG-80366 (BEX1)
Protein Structure
UniProt Annotation
Function Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia. {ECO:0000269PubMed:11989783, ECO:0000269PubMed:15920485, ECO:0000269PubMed:15958283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
Biological Process
GO:0007399 nervous system development
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007623 Brain-expressed X-linked protein
IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like
PFAM PF04538
PRINTS
PIRSF PIRSF008633
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HBH7
PhosphoSite PhosphoSite-Q9HBH7
TrEMBL
UniProt Splice Variant
Entrez Gene 55859
UniGene
RefSeq NP_060946
HUGO HGNC:1036
OMIM 300690
CCDS CCDS35354
HPRD 06460
IMGT
EMBL AF183416 AF220189 AF237783 AK290958 AL008708 AY833561 BC126427 BC126429
GenPept AAF67654 AAG09685 AAG09752 AAI26428 AAI26430 AAX40679 BAF83647 CAI42418

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca