Homo sapiens Protein: TXNDC8 | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-80374.5 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | TXNDC8 | ||||||||
Protein Name | thioredoxin domain containing 8 (spermatozoa) | ||||||||
Synonyms | |||||||||
Species | Homo sapiens | ||||||||
Ensembl Protein | ENSP00000363635 | ||||||||
InnateDB Gene | IDBG-80372 (TXNDC8) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm. | ||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:15181017}. Golgi apparatus {ECO:0000269PubMed:15181017}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). {ECO:0000269PubMed:15181017}. | ||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | |||||||||
InterPro |
IPR012336
Thioredoxin-like fold IPR013766 Thioredoxin domain |
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PFAM |
PF13098
PF13192 PF13462 PF13905 PF00085 |
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PRINTS | |||||||||
PIRSF | |||||||||
SMART | |||||||||
TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q6A555 | ||||||||
PhosphoSite | PhosphoSite- | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 255220 | ||||||||
UniGene | |||||||||
RefSeq | XP_005251936 | ||||||||
HUGO | HGNC:31454 | ||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | 18251 | ||||||||
IMGT | |||||||||
EMBL | AF305830 AL158158 BC130549 BC130551 | ||||||||
GenPept | AAI30550 AAI30552 AAQ14501 CAI14069 | ||||||||