Version 5.4
| Homo sapiens Protein: TXNDC8 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-80376.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | TXNDC8 | ||||||||||
| Protein Name | thioredoxin domain containing 8 (spermatozoa) | ||||||||||
| Synonyms | |||||||||||
| Species | Homo sapiens | ||||||||||
| Ensembl Protein | ENSP00000363634 | ||||||||||
| InnateDB Gene | IDBG-80372 (TXNDC8) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm. | ||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:15181017}. Golgi apparatus {ECO:0000269PubMed:15181017}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Testis-specific. Only expressed during spermiogenesis, prominently in the Golgi apparatus of pachytene spermatocytes and round and elongated spermatids, with a transient localization in the developing acrosome of round spermatids (at protein level). {ECO:0000269PubMed:15181017}. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR012336
Thioredoxin-like fold IPR013766 Thioredoxin domain |
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| PFAM |
PF13098
PF13192 PF13462 PF13905 PF00085 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q6A555 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 255220 | ||||||||||
| UniGene | |||||||||||
| RefSeq | NP_001003936 | ||||||||||
| HUGO | HGNC:31454 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS35104 | ||||||||||
| HPRD | 18251 | ||||||||||
| IMGT | |||||||||||
| EMBL | AF305830 AL158158 BC130549 BC130551 | ||||||||||
| GenPept | AAI30550 AAI30552 AAQ14501 CAI14069 | ||||||||||