Version 5.4
Homo sapiens Protein: L3HYPDH
Summary
InnateDB Protein IDBP-8041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol L3HYPDH
Protein Name chromosome 14 open reading frame 149
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000247194
InnateDB Gene IDBG-8039 (L3HYPDH)
Protein Structure
UniProt Annotation
Function Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. {ECO:0000269PubMed:22528483}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:22528483}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016836 hydro-lyase activity
GO:0018112 proline racemase activity
GO:0050346 trans-L-3-hydroxyproline dehydratase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR008794 Proline racemase family
PFAM PF05544
PRINTS
PIRSF PIRSF029792
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EM0
PhosphoSite PhosphoSite-Q96EM0
TrEMBL D6RC46
UniProt Splice Variant
Entrez Gene 112849
UniGene Hs.729061
RefSeq NP_653182
HUGO HGNC:20488
OMIM 614811
CCDS CCDS9739
HPRD 08065
IMGT
EMBL AK058165 AL159140 BC012131
GenPept AAH12131 BAB71696

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca