InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAT1A

Summary

InnateDB Protein

IDBP-80411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAT1A

Protein Name

methionine adenosyltransferase I, alpha

Synonyms

MAT; MATA1; SAMS; SAMS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000361287

InnateDB Gene

IDBG-80409 (MAT1A)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

Subcellular Localization

Disease Associations

Methionine adenosyltransferase deficiency (MATD) [MIM:250850]: An inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. {ECO:0000269PubMed:10677294, ECO:0000269PubMed:7560086, ECO:0000269PubMed:8770875, ECO:0000269PubMed:9042912}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004478	methionine adenosyltransferase activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0006556	S-adenosylmethionine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0006805	xenobiotic metabolic process
GO:0032259	methylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR002133 S-adenosylmethionine synthetase
IPR022628 S-adenosylmethionine synthetase, N-terminal
IPR022629 S-adenosylmethionine synthetase, central domain
IPR022630 S-adenosylmethionine synthetase, C-terminal
IPR022636 S-adenosylmethionine synthetase superfamily

PFAM

PF00438
PF02772
PF02773

PRINTS

PIRSF

PIRSF000497

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q00266