InnateDB Protein
|
IDBP-80510.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TCEAL7
|
Protein Name
|
transcription elongation factor A (SII)-like 7
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000361751
|
InnateDB Gene
|
IDBG-80504 (TCEAL7)
|
Protein Structure
|
|
Function |
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. {ECO:0000269PubMed:18806825, ECO:0000269PubMed:19966855, ECO:0000269PubMed:20454512}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:18806825}.
|
Disease Associations |
|
Tissue Specificity |
Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors. {ECO:0000269PubMed:18806825}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0032088
|
negative regulation of NF-kappaB transcription factor activity
|
GO:0045892
|
negative regulation of transcription, DNA-templated
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR021156
Transcription elongation factor A-like/Brain expressed X-linked-like
|
PFAM |
PF04538
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9BRU2
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
56849
|
UniGene |
Hs.602651
|
RefSeq |
|
HUGO |
HGNC:28336
|
OMIM |
300771
|
CCDS |
CCDS14506
|
HPRD |
06641
|
IMGT |
|
EMBL |
AK094400
BC005988
BC016786
CH471190
Z92846
|
GenPept |
AAH05988
AAH16786
BAG52864
CAI41965
EAW54714
|
|
|