Version 5.4
Homo sapiens Protein: JKAMP
Summary
InnateDB Protein IDBP-8057.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JKAMP
Protein Name JNK1/MAPK8-associated membrane protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000348351
InnateDB Gene IDBG-8053 (JKAMP)
Protein Structure
UniProt Annotation
Function May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006986 response to unfolded protein
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008485 Protein of unknown function DUF766
PFAM PF05571
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P055
PhosphoSite PhosphoSite-Q9P055
TrEMBL G3V2R2
UniProt Splice Variant
Entrez Gene 51528
UniGene
RefSeq NP_001271131
HUGO HGNC:20184
OMIM 611176
CCDS CCDS61463
HPRD 12623
IMGT
EMBL AF151047 AF161445 AF212245 AF529304 AK021683 AK027591 AK298209 AL121694 AL136696 AL159140 AL162471 BC005198 BC010359 BX161501 CH471061 CR457163 CR533510
GenPept AAF29005 AAF36133 AAG41781 AAH05198 AAH10359 AAP85636 BAB13874 BAB55216 BAG60479 CAB66631 CAD61945 CAG33444 CAG38541 EAW80753 EAW80756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca