Version 5.4
Homo sapiens Protein: MARCH4
Summary
InnateDB Protein IDBP-80638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH4
Protein Name membrane-associated ring finger (C3HC4) 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000273067
InnateDB Gene IDBG-80636 (MARCH4)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269PubMed:14722266}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:14722266}; Multi-pass membrane protein {ECO:0000269PubMed:14722266}.
Disease Associations
Tissue Specificity Expressed in brain and placenta. {ECO:0000269PubMed:14722266}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005795 Golgi stack
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF12906
PF00097
PRINTS
PIRSF
SMART SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2E8
PhosphoSite PhosphoSite-Q9P2E8
TrEMBL
UniProt Splice Variant
Entrez Gene 57574
UniGene Hs.170388
RefSeq NP_065865
HUGO HGNC:29269
OMIM 608208
CCDS CCDS33376
HPRD 16299
IMGT
EMBL AB037820 BC048793 BC098448
GenPept AAH48793 AAH98448 BAA92637

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca