InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF114

Summary

InnateDB Protein

IDBP-80641.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF114

Protein Name

ring finger protein 114

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000244061

InnateDB Gene

IDBG-80639 (RNF114)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis. {ECO:0000269PubMed:23645206}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23645206}. Nucleus {ECO:0000269PubMed:23645206}.

Disease Associations

Tissue Specificity

Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis. {ECO:0000269PubMed:18364390}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0030154	cell differentiation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR008598 Drought induced 19 protein-like, zinc-binding domain
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF05605
PF00097

PRINTS

PIRSF

SMART

SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y508

PhosphoSite

PhosphoSite-Q9Y508

TrEMBL

H0UI65

UniProt Splice Variant

Entrez Gene

55905

UniGene

Hs.144949

RefSeq

NP_061153

HUGO

HGNC:13094

OMIM

612451

CCDS

CCDS33482

HPRD

10329

IMGT

EMBL

AF265215 AK301731 AK315638 AL031685 BC013695 BC066919 BT006795 BX640603 CH471077

GenPept

AAF75763 AAH13695 AAH66919 AAP35441 BAG38006 BAG63197 CAB46028 CAE45709 EAW75641 EAW75642 EAW75643 EAW75644