Version 5.4
Homo sapiens Protein: APOBEC3A
Summary
InnateDB Protein IDBP-806530.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC3A
Protein Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000481904
InnateDB Gene IDBG-7865 (APOBEC3A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0047844 deoxycytidine deaminase activity
Biological Process
GO:0009972 cytidine deamination
GO:0010529 negative regulation of transposition
GO:0044356 clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
GO:0071466 cellular response to xenobiotic stimulus
GO:0080111 DNA demethylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007904 APOBEC-like, C-terminal
IPR013158 APOBEC-like, N-terminal
IPR016193 Cytidine deaminase-like
PFAM PF05240
PF08210
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 200315
UniGene
RefSeq NP_001180218
HUGO HGNC:17343
OMIM 607109
CCDS
HPRD
IMGT
EMBL AL022318 BC126416 CR456393 U03891
GenPept AAA03706 AAI26417 CAG30279 CAI17897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca