Version 5.4
Homo sapiens Protein: GHITM
Summary
InnateDB Protein IDBP-80664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GHITM
Protein Name growth hormone inducible transmembrane protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361207
InnateDB Gene IDBG-80662 (GHITM)
Protein Structure
UniProt Annotation
Function Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. {ECO:0000269PubMed:18417609}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:18417609}; Multi-pass membrane protein {ECO:0000269PubMed:18417609}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0008150 biological_process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006214 Bax inhibitor 1-related
PFAM PF01027
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3K2
PhosphoSite PhosphoSite-Q9H3K2
TrEMBL Q9P099
UniProt Splice Variant
Entrez Gene 27069
UniGene Hs.352656
RefSeq NP_055209
HUGO HGNC:17281
OMIM
CCDS CCDS41542
HPRD 17038
IMGT
EMBL AB009685 AC022389 AF060923 AF131820 AF161400 AK292864 AK298332 AL136713 AL603756 AL834502 AY358824 BC010354 CH471142
GenPept AAD20052 AAF28960 AAG43135 AAH10354 AAQ89183 BAA93049 BAF85553 BAG60581 CAB66648 CAH56398 CAH72660 EAW80367 EAW80368 EAW80369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca