Version 5.4
Homo sapiens Protein: EPRS
Summary
InnateDB Protein IDBP-806848.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPRS
Protein Name glutamyl-prolyl-tRNA synthetase
Synonyms EARS; GLUPRORS; PARS; QARS; QPRS;
Species Homo sapiens
Ensembl Protein ENSP00000477245
InnateDB Gene IDBG-106727 (EPRS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 95 [view]
Protein-Protein 94 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004818 glutamate-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000738 WHEP-TRS
IPR000924 Glutamyl/glutaminyl-tRNA synthetase
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
IPR009068 S15/NS1, RNA-binding
IPR010987 Glutathione S-transferase, C-terminal-like
IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain
IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
PFAM PF00458
PF00749
PF03950
PRINTS PR00987
PIRSF
SMART SM00991
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL V9GYZ6
UniProt Splice Variant
Entrez Gene 2058
UniGene
RefSeq
HUGO HGNC:3418
OMIM 138295
CCDS
HPRD
IMGT
EMBL AC103590
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca