InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIAA0368

Summary

InnateDB Protein

IDBP-80687.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIAA0368

Protein Name

KIAA0368

Synonyms

ECM29;

Species

Homo sapiens

Ensembl Protein

ENSP00000339889

InnateDB Gene

IDBG-80685 (KIAA0368)

Protein Structure

UniProt Annotation

Function

Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis. {ECO:0000269PubMed:15496406, ECO:0000269PubMed:20682791}.

Subcellular Localization

Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 96 experimentally validated interaction(s) in this database.

Experimentally validated
Total	96 [view]
Protein-Protein	96 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding

Biological Process

GO:0030433

ER-associated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005813	centrosome
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030134	ER to Golgi transport vesicle
GO:0030139	endocytic vesicle