InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYTH3

Summary

InnateDB Protein

IDBP-8071.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYTH3

Protein Name

cytohesin 3

Synonyms

ARNO3; GRP1; PSCD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000297044

InnateDB Gene

IDBG-8069 (CYTH3)

Protein Structure

UniProt Annotation

Function

Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269PubMed:23940353, ECO:0000269PubMed:9707577}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.

Disease Associations

Tissue Specificity

Almost absent from liver, thymus and peripheral blood lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0030155	regulation of cell adhesion
GO:0032012	regulation of ARF protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045785	positive regulation of cell adhesion
GO:0048193	Golgi vesicle transport
GO:0090162	establishment of epithelial cell polarity