Version 5.4
Homo sapiens Protein: MEP1A
Summary
InnateDB Protein IDBP-807103.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEP1A
Protein Name meprin A, alpha (PABA peptide hydrolase)
Synonyms PPHA;
Species Homo sapiens
Ensembl Protein ENSP00000480465
InnateDB Gene IDBG-90012 (MEP1A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001506 Peptidase M12A, astacin
IPR002083 MATH
IPR006026 Peptidase, metallopeptidase
IPR008294 Meprin alpha/beta subunit
IPR008974 TRAF-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00008
PF00629
PF01400
PF00917
PRINTS PR00020
PR00480
PIRSF PIRSF001196
SMART SM00181
SM00137
SM00061
SM00235
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B7ZL91
UniProt Splice Variant
Entrez Gene 4224
UniGene
RefSeq
HUGO HGNC:7015
OMIM 600388
CCDS
HPRD
IMGT
EMBL BC143651
GenPept AAI43652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca