InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2V1

Summary

InnateDB Protein

IDBP-80716.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2V1

Protein Name

ubiquitin-conjugating enzyme E2 variant 1

Synonyms

CIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000340305

InnateDB Gene

IDBG-408829 (UBE2V1)

Protein Structure

UniProt Annotation

Function

Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {ECO:0000269PubMed:11057907, ECO:0000269PubMed:20061386, ECO:0000269PubMed:21512573, ECO:0000269PubMed:9305758, ECO:0000269PubMed:9418904, ECO:0000269PubMed:9580084, ECO:0000269PubMed:9705497}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11076860, ECO:0000269PubMed:9305758}. Note=Excluded from the nucleolus.

Disease Associations

Tissue Specificity

Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. {ECO:0000269PubMed:9418904, ECO:0000269PubMed:9705497}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.

Experimentally validated
Total	128 [view]
Protein-Protein	128 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity
GO:0031624	ubiquitin conjugating enzyme binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006282	regulation of DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0030154	cell differentiation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042275	error-free postreplication DNA repair
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534	protein K63-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031371	ubiquitin conjugating enzyme complex
GO:0035370	UBC13-UEV1A complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome