InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGFBP5

Summary

InnateDB Protein

IDBP-80735.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP5

Protein Name

insulin-like growth factor binding protein 5

Synonyms

IBP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000233813

InnateDB Gene

IDBG-80733 (IGFBP5)

Protein Structure

UniProt Annotation

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Osteosarcoma, and at lower levels in liver, kidney and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0031994	insulin-like growth factor I binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001649	osteoblast differentiation
GO:0006006	glucose metabolic process
GO:0007165	signal transduction
GO:0010906	regulation of glucose metabolic process
GO:0014912	negative regulation of smooth muscle cell migration
GO:0017148	negative regulation of translation
GO:0030336	negative regulation of cell migration
GO:0031069	hair follicle morphogenesis
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0042593	glucose homeostasis
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway
GO:0044267	cellular protein metabolic process
GO:0044342	type B pancreatic cell proliferation
GO:0045668	negative regulation of osteoblast differentiation
GO:0048630	skeletal muscle tissue growth
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051146	striated muscle cell differentiation
GO:0051897	positive regulation of protein kinase B signaling
GO:0060056	mammary gland involution
GO:0071320	cellular response to cAMP
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005576	extracellular region
GO:0016942	insulin-like growth factor binding protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000716 Thyroglobulin type-1
IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR012213 Insulin-like growth factor binding protein 5
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata

PFAM

PF00086
PF00219

PRINTS

PR01981
PR01976

PIRSF

SMART

SM00211
SM00121

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt