Version 5.4
Homo sapiens Protein: CBX7
Summary
InnateDB Protein IDBP-8074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBX7
Protein Name chromobox homolog 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216133
InnateDB Gene IDBG-8072 (CBX7)
Protein Structure
UniProt Annotation
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. {ECO:0000269PubMed:19636380, ECO:0000269PubMed:21047797, ECO:0000269PubMed:21060834, ECO:0000269PubMed:21282530}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14647293, ECO:0000269PubMed:21060834, ECO:0000269PubMed:21282530}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0035064 methylated histone binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0048733 sebaceous gland development
Cellular Component
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Protein Structure and Domains
PDB ID
InterPro IPR000953 Chromo domain/shadow
IPR016197 Chromo domain-like
IPR017984 Chromo domain subgroup
IPR023780 Chromo domain
PFAM PF00385
PRINTS PR00504
PIRSF
SMART SM00298
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95931
PhosphoSite PhosphoSite-O95931
TrEMBL A0A024R1Q2
UniProt Splice Variant
Entrez Gene 23492
UniGene Hs.681020
RefSeq NP_783640
HUGO HGNC:1557
OMIM 608457
CCDS CCDS13986
HPRD 12234
IMGT
EMBL AL031846 BC051773 CH471095
GenPept AAH51773 CAB36555 EAW60298 EAW60299 EAW60300 EAW60301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca