InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TEK

Summary

InnateDB Protein

IDBP-807632.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TEK

Protein Name

TEK tyrosine kinase, endothelial

Synonyms

CD202B; TIE-2; TIE2; VMCM; VMCM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000480251

InnateDB Gene

IDBG-55143 (TEK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR007110 Immunoglobulin-like domain
IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal

PFAM

PF00008
PF10430

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite