InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNS1

Summary

InnateDB Protein

IDBP-80771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNS1

Protein Name

tensin 1

Synonyms

MST091; MST122; MST127; MSTP122; MSTP127; MXRA6; PPP1R155; TNS;

Species

Homo sapiens

Ensembl Protein

ENSP00000171887

InnateDB Gene

IDBG-80769 (TNS1)

Protein Structure

UniProt Annotation

Function

Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. {ECO:0000269PubMed:21768292}.

Subcellular Localization

Cell surface {ECO:0000269PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269PubMed:21768292}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:21768292}. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11023826}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	16 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0010761	fibroblast migration

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0009986	cell surface
GO:0030055	cell-substrate junction

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000980 SH2 domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR014020 Tensin phosphatase, C2 domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain

PFAM