Version 5.4
Homo sapiens Protein: DEFA3
Summary
InnateDB Protein IDBP-807848.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFA3
Protein Name defensin, alpha 3, neutrophil-specific
Synonyms DEF1; DEF3; DEFA2; HNP-1; HNP-3; HNP3; HP-1; HP-3; HP1; HP3; MRS;
Species Homo sapiens
Ensembl Protein ENSP00000484218
InnateDB Gene IDBG-402318 (DEFA3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006935 chemotaxis
GO:0006952 defense response
GO:0006955 immune response
GO:0019731 antibacterial humoral response
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0031640 killing of cells of other organism
GO:0045087 innate immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0031012 extracellular matrix
GO:0035578 azurophil granule lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002366 Defensin propeptide
IPR006080 Beta defensin/Neutrophil defensin
IPR006081 Mammalian defensins
IPR016327 Alpha-defensin
PFAM PF00879
PF00323
PRINTS
PIRSF PIRSF001875
SMART SM00048
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 728358
UniGene
RefSeq
HUGO HGNC:2762
OMIM 604522
CCDS
HPRD
IMGT
EMBL AF200455 AF238378 BC069423 BC093791 BC112188 L12690 M21130 M26602 X52053
GenPept AAA36382 AAA52302 AAA52303 AAH69423 AAH93791 AAI12189 AAT68875 AAT68878 AAT68879 AAT68880 AAT68883 AAT68884 CAA36280

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca