InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGR

Summary

InnateDB Protein

IDBP-80809.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGR

Protein Name

retinal G protein coupled receptor

Synonyms

RP44;

Species

Homo sapiens

Ensembl Protein

ENSP00000352427

InnateDB Gene

IDBG-80807 (RGR)

Protein Structure

UniProt Annotation

Function

Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Retinitis pigmentosa 44 (RP44) [MIM:613769]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. {ECO:0000269PubMed:10581022}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0009881	photoreceptor activity

Biological Process

GO:0006935	chemotaxis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0018298	protein-chromophore linkage
GO:0070098	chemokine-mediated signaling pathway