InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX3X

Summary

InnateDB Protein

IDBP-808421.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX3X

Protein Name

DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

Synonyms

CAP-Rf; DBX; DDX14; DDX3; HLP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000478443

InnateDB Gene

IDBG-229341 (DDX3X)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	174 [view]
Protein-Protein	169 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004004	ATP-dependent RNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0008143	poly(A) binding
GO:0008190	eukaryotic initiation factor 4E binding
GO:0016887	ATPase activity
GO:0031369	translation initiation factor binding
GO:0035613	RNA stem-loop binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0007059	chromosome segregation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009615	response to virus
GO:0010501	RNA secondary structure unwinding
GO:0016032	viral process
GO:0017148	negative regulation of translation
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0031333	negative regulation of protein complex assembly
GO:0032508	DNA duplex unwinding
GO:0032728	positive regulation of interferon-beta production
GO:0034063	stress granule assembly
GO:0035556	intracellular signal transduction
GO:0042256	mature ribosome assembly
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045727	positive regulation of translation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045948	positive regulation of translational initiation
GO:0071243	cellular response to arsenic-containing substance
GO:0071470	cellular response to osmotic stress
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0010494	cytoplasmic stress granule
GO:0016607	nuclear speck
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite