InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR2E

Summary

InnateDB Protein

IDBP-808476.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2E

Protein Name

polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

Synonyms

hRPB25; hsRPB5; RPABC1; RPB5; XAP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000478303

InnateDB Gene

IDBG-13793 (POLR2E)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	106 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001054	RNA polymerase I activity
GO:0001055	RNA polymerase II activity
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0006383	transcription from RNA polymerase III promoter
GO:0006385	transcription elongation from RNA polymerase III promoter
GO:0006386	termination of RNA polymerase III transcription
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex
GO:0005666	DNA-directed RNA polymerase III complex
GO:0005736	DNA-directed RNA polymerase I complex
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000783 RNA polymerase, subunit H/Rpb5 C-terminal
IPR005571 RNA polymerase, Rpb5, N-terminal
IPR014381 DNA-directed RNA polymerase RPB5 subunit, eukaryote/virus

PFAM

PF01191
PF03871

PRINTS

PIRSF

PIRSF000747

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite