InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADSL

Summary

InnateDB Protein

IDBP-808984.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADSL

Protein Name

adenylosuccinate lyase

Synonyms

AMPS; ASASE; ASL;

Species

Homo sapiens

Ensembl Protein

ENSP00000485525

InnateDB Gene

IDBG-406802 (ADSL)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

Biological Process

GO:0001666	response to hypoxia
GO:0006144	purine nucleobase metabolic process
GO:0006163	purine nucleotide metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009060	aerobic respiration
GO:0009152	purine ribonucleotide biosynthetic process
GO:0009156	ribonucleoside monophosphate biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0014850	response to muscle activity
GO:0042594	response to starvation
GO:0044208	'de novo' AMP biosynthetic process
GO:0044281	small molecule metabolic process
GO:0051262	protein tetramerization
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000362 Fumarate lyase family
IPR004769 Adenylosuccinate lyase
IPR008948 L-Aspartase-like
IPR019468 Adenylosuccinate lyase C-terminal
IPR022761 Fumarate lyase, N-terminal

PFAM

PF10397
PF00206

PRINTS

PR00149

PIRSF

SMART

SM00998

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt