Homo sapiens Protein: USP25 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-809.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | USP25 | ||||||||||||||||||
Protein Name | ubiquitin specific peptidase 25 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000285679 | ||||||||||||||||||
InnateDB Gene | IDBG-805 (USP25) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. | ||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:16501887, ECO:0000269PubMed:19440361}.Isoform USP25m: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Isoform USB25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USB25b is found in all tissues except heart and skeletal muscle. Isoform USB25m is heart and skeletal muscle specific. {ECO:0000269PubMed:10644437, ECO:0000269PubMed:11597335}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase IPR003903 Ubiquitin interacting motif IPR009060 UBA-like IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain |
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PFAM |
PF00443
PF02809 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00726
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UHP3 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UHP3 | ||||||||||||||||||
TrEMBL | W6MEN2 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 29761 | ||||||||||||||||||
UniGene | Hs.728821 | ||||||||||||||||||
RefSeq | NP_037528 | ||||||||||||||||||
HUGO | HGNC:12624 | ||||||||||||||||||
OMIM | 604736 | ||||||||||||||||||
CCDS | CCDS33515 | ||||||||||||||||||
HPRD | 05296 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF134213 AF170562 AK022447 AK022574 BC075792 CH471079 FJ763652 HG765100 | ||||||||||||||||||
GenPept | AAF24998 AAF32263 AAH75792 ACN76567 BAB14037 BAB14107 CDJ98632 EAX10041 | ||||||||||||||||||