Version 5.4
Homo sapiens Protein: H2BFWT
Summary
InnateDB Protein IDBP-80902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2BFWT
Protein Name H2B histone family, member W, testis-specific
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354723
InnateDB Gene IDBG-80916 (H2BFWT)
Protein Structure
UniProt Annotation
Function Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes. May be important for telomere function. {ECO:0000269PubMed:16449661}.
Subcellular Localization Nucleus membrane {ECO:0000269PubMed:15475252}. Chromosome {ECO:0000269PubMed:15475252}.
Disease Associations
Tissue Specificity Testis-specific. Present in sperm cells (at protein level). {ECO:0000269PubMed:15475252}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR000558 Histone H2B
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00621
PIRSF
SMART SM00427
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z2G1
PhosphoSite PhosphoSite-Q7Z2G1
TrEMBL
UniProt Splice Variant
Entrez Gene 158983
UniGene Hs.127778
RefSeq NP_001002916
HUGO HGNC:27252
OMIM 300507
CCDS CCDS35362
HPRD 15956
IMGT
EMBL AL034485 AY283369 AY283370 BC038109 BC118604 BC121816 CH471120
GenPept AAH38109 AAI18605 AAI21817 AAP37489 AAP37490 CAI43100 EAX02765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca