Version 5.4
Homo sapiens Protein: PDGFB
Summary
InnateDB Protein IDBP-8093.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDGFB
Protein Name platelet-derived growth factor beta polypeptide
Synonyms c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV;
Species Homo sapiens
Ensembl Protein ENSP00000330382
InnateDB Gene IDBG-8091 (PDGFB)
Protein Structure
UniProt Annotation
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.
Subcellular Localization Secreted. Note=Released by platelets upon wounding.
Disease Associations Basal ganglia calcification, idiopathic, 5 (IBGC5) [MIM:615483]: A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO:0000269PubMed:23913003}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. {ECO:0000269PubMed:12660034}.
Tissue Specificity Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. {ECO:0000269PubMed:11331882}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008083 growth factor activity
GO:0016176 superoxide-generating NADPH oxidase activator activity
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001568 blood vessel development
GO:0001666 response to hypoxia
GO:0001892 embryonic placenta development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002548 monocyte chemotaxis
GO:0002576 platelet degranulation
GO:0003104 positive regulation of glomerular filtration
GO:0006260 DNA replication
GO:0006468 protein phosphorylation
GO:0006929 substrate-dependent cell migration
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009611 response to wounding
GO:0010033 response to organic substance
GO:0010512 negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 negative regulation of platelet activation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 response to organic cyclic compound
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030031 cell projection assembly
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0031954 positive regulation of protein autophosphorylation
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032355 response to estradiol
GO:0032868 response to insulin
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 paracrine signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045087 innate immune response
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740 positive regulation of DNA replication
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840 positive regulation of mitosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051781 positive regulation of cell division
GO:0060326 cell chemotaxis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071506 cellular response to mycophenolic acid
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0072255 metanephric glomerular mesangial cell development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264 metanephric glomerular endothelium development
GO:0072593 reactive oxygen species metabolic process
GO:0090280 positive regulation of calcium ion import
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000591 positive regulation of metanephric mesenchymal cell migration
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0009986 cell surface
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0031093 platelet alpha granule lumen
Protein Structure and Domains
PDB ID
InterPro IPR000072 PDGF/VEGF domain
IPR006782 Platelet-derived growth factor, N-terminal
IPR029034 Cystine-knot cytokine
PFAM PF00341
PF04692
PRINTS
PIRSF
SMART SM00141
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01127
PhosphoSite PhosphoSite-P01127
TrEMBL Q9UE57
UniProt Splice Variant
Entrez Gene 5155
UniGene Hs.1976
RefSeq NP_002599
HUGO HGNC:8800
OMIM 190040
CCDS CCDS13987
HPRD 01815
IMGT
EMBL BC029822 BC077725 CH471095 CR456538 CR541807 J00121 K01398 K01399 K01400 K01401 K01913 K01914 K01915 K01916 K01917 K01918 M12783 M19719 X00560 X00561 X00562 X02744 X02811 X03702 X83705 X98706 Z81010
GenPept AAA60349 AAA60552 AAA60553 AAA98793 AAH29822 AAH77725 CAA25227 CAA25228 CAA25229 CAA25230 CAA26524 CAA26579 CAA27333 CAA58679 CAA67262 CAB02635 CAG30424 CAG46606 CAP58849 EAW60305 EAW60306 EAW60307 EAW60308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca