InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHFRL1

Summary

InnateDB Protein

IDBP-809509.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHFRL1

Protein Name

dihydrofolate reductase-like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000480823

InnateDB Gene

IDBG-46235 (DHFRL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0004146	dihydrofolate reductase activity
GO:0050661	NADP binding

Biological Process

GO:0006545	glycine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0009165	nucleotide biosynthetic process
GO:0046105	thymidine biosynthetic process
GO:0046653	tetrahydrofolate metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001796 Dihydrofolate reductase domain
IPR012259 Dihydrofolate reductase
IPR024072 Dihydrofolate reductase-like domain

PFAM

PF00186

PRINTS

PR00070

PIRSF

PIRSF000194

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

C9JJ68

UniProt Splice Variant

Entrez Gene

200895

UniGene

RefSeq

HUGO

HGNC:27309

OMIM

CCDS

CCDS2926

HPRD

IMGT

EMBL

AC130896 AL832912 BC045541 BC063379 CH471052

GenPept

AAH45541 AAH63379 CAH10617 EAW79895 EAW79896