InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCH1

Summary

InnateDB Protein

IDBP-809515.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCH1

Protein Name

GTP cyclohydrolase 1

Synonyms

DYT14; DYT5; DYT5a; GCH; GTP-CH-1; GTPCH1; HPABH4B;

Species

Homo sapiens

Ensembl Protein

ENSP00000477796

InnateDB Gene

IDBG-7150 (GCH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003934	GTP cyclohydrolase I activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0006809	nitric oxide biosynthetic process
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0032496	response to lipopolysaccharide
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor
GO:0035998	7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042416	dopamine biosynthetic process
GO:0042559	pteridine-containing compound biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0048265	response to pain
GO:0050884	neuromuscular process controlling posture
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051260	protein homooligomerization