InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESX1

Summary

InnateDB Protein

IDBP-80976.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESX1

Protein Name

ESX homeobox 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361669

InnateDB Gene

IDBG-80974 (ESX1)

Protein Structure

UniProt Annotation

Function

May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. {ECO:0000269PubMed:15235584, ECO:0000269PubMed:15897875}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15235584}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00108, ECO:0000269PubMed:15235584}. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.

Disease Associations

Tissue Specificity

Expressed in placenta and testis. Expressed in testicular germ cell tumors. {ECO:0000269PubMed:11374906, ECO:0000269PubMed:15235584}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051726	regulation of cell cycle
GO:0060713	labyrinthine layer morphogenesis
GO:0060716	labyrinthine layer blood vessel development