InnateDB Protein
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IDBP-80979.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OPN4
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Protein Name
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opsin 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361141
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InnateDB Gene
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IDBG-80977 (OPN4)
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Protein Structure
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Function |
Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina. {ECO:0000269PubMed:10632589}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004930
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G-protein coupled receptor activity
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GO:0005502
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11-cis retinal binding
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GO:0008020
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G-protein coupled photoreceptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR001760
Opsin
IPR017452
GPCR, rhodopsin-like, 7TM
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PFAM |
PF00001
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PRINTS |
PR00237
PR00238
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UHM6
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PhosphoSite |
PhosphoSite-Q9UHM6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
94233
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UniGene |
Hs.283922
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RefSeq |
NP_001025186
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HUGO |
HGNC:14449
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OMIM |
606665
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CCDS |
CCDS31237
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HPRD |
05977
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IMGT |
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EMBL |
AB065730
AF147788
BC113558
BC143688
DQ314804
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GenPept |
AAF24978
AAI13559
AAI43689
ABC40723
BAC05951
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