Homo sapiens Protein: OPN4
Summary
InnateDB Protein IDBP-80981.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OPN4
Protein Name opsin 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000241891
InnateDB Gene IDBG-80977 (OPN4)
Protein Structure
UniProt Annotation
Function Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells. {ECO:0000250}.
Disease Associations
Tissue Specificity Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina. {ECO:0000269PubMed:10632589}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005502 11-cis retinal binding
GO:0008020 G-protein coupled photoreceptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0018298 protein-chromophore linkage
GO:0042752 regulation of circadian rhythm
GO:0048511 rhythmic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001760 Opsin
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR00238
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHM6
PhosphoSite PhosphoSite-Q9UHM6
TrEMBL
UniProt Splice Variant
Entrez Gene 94233
UniGene Hs.283922
RefSeq NP_150598
HUGO HGNC:14449
OMIM 606665
CCDS CCDS7376
HPRD 05977
IMGT
EMBL AB065730 AF147788 BC113558 BC143688 DQ314804
GenPept AAF24978 AAI13559 AAI43689 ABC40723 BAC05951