Version 5.4
Homo sapiens Protein: IL1RAPL2
Summary
InnateDB Protein IDBP-80988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RAPL2
Protein Name interleukin 1 receptor accessory protein-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344976
InnateDB Gene IDBG-80984 (IL1RAPL2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Detected at low levels in fetal and adult brain, in particular in the frontal lobe, temporal lobe and cerebellum. Detected at very low levels in skin, liver, fetal ovary and in placenta. {ECO:0000269PubMed:10882729, ECO:0000269PubMed:11031108, ECO:0000269PubMed:11587848}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004908 interleukin-1 receptor activity
GO:0004910 interleukin-1, Type II, blocking receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR007110 Immunoglobulin-like domain
PFAM PF01582
PF13676
PRINTS
PIRSF
SMART SM00255
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NP60
PhosphoSite PhosphoSite-Q9NP60
TrEMBL
UniProt Splice Variant
Entrez Gene 26280
UniGene Hs.675519
RefSeq
HUGO HGNC:5997
OMIM 300277
CCDS
HPRD 02231
IMGT
EMBL AF181285 AF212016 AF284436 AJ272208 AJ290436 AK290196 AL050401 BC104784 BC104786 Z68328 Z68330 Z68908 Z69721 Z74477 Z74619 Z81144
GenPept AAF59412 AAF61307 AAG21370 AAI04785 AAI04787 BAF82885 CAB86868 CAB89867 CAI41969 CAI41981 CAI41987 CAI41989 CAI42001 CAI42006 CAI42894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca