Version 5.4
Homo sapiens Protein: PLCD3
Summary
InnateDB Protein IDBP-809881.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCD3
Protein Name phospholipase C, delta 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000479636
InnateDB Gene IDBG-54655 (PLCD3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0001525 angiogenesis
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell proliferation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0060716 labyrinthine layer blood vessel development
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032154 cleavage furrow
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001849 Pleckstrin homology domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM PF00168
PF00388
PF00387
PF00169
PF09279
PRINTS PR00360
PR00390
PIRSF
SMART SM00239
SM00148
SM00149
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N3E9
PhosphoSite PhosphoSite-Q8N3E9
TrEMBL F5GXC1
UniProt Splice Variant
Entrez Gene 113026
UniGene
RefSeq NP_588614
HUGO HGNC:9061
OMIM 608795
CCDS CCDS74077
HPRD
IMGT
EMBL AB075844 AC002117 AC142472 AK074240 AL834392 BC010668 BC072384
GenPept AAH10668 AAH72384 BAB85029 BAB85550 CAD39054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca