Version 5.4
Homo sapiens Protein: SH2B1
Summary
InnateDB Protein IDBP-810001.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2B1
Protein Name SH2B adaptor protein 1
Synonyms PSM; SH2B;
Species Homo sapiens
Ensembl Protein ENSP00000481709
InnateDB Gene IDBG-23518 (SH2B1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007596 blood coagulation
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
IPR015012 Phenylalanine zipper
PFAM PF00017
PF14633
PF00169
PF08916
PRINTS PR00401
PIRSF
SMART SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H3BVF6
UniProt Splice Variant
Entrez Gene 25970
UniGene
RefSeq NP_001139267
HUGO HGNC:30417
OMIM 608937
CCDS CCDS53996
HPRD
IMGT
EMBL AB037720 AC133550 AF227967 AF227968 AF227969 AK027488 AK290332 AL049924 AL713760 BC010704 CH471267
GenPept AAF73912 AAF73913 AAF73914 AAH10704 BAA92537 BAB55148 BAF83021 CAB43208 CAD28530 EAW52001 EAW52005

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca