InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR4A3

Summary

InnateDB Protein

IDBP-810599.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR4A3

Protein Name

nuclear receptor subfamily 4, group A, member 3

Synonyms

CHN; CSMF; MINOR; NOR1; TEC;

Species

Homo sapiens

Ensembl Protein

ENSP00000482027

InnateDB Gene

IDBG-78601 (NR4A3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004887	thyroid hormone receptor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001707	mesoderm formation
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007411	axon guidance
GO:0008150	biological_process
GO:0010467	gene expression
GO:0021766	hippocampus development
GO:0030522	intracellular receptor signaling pathway
GO:0030534	adult behavior
GO:0031100	organ regeneration
GO:0042472	inner ear morphogenesis
GO:0042542	response to hydrogen peroxide
GO:0043066	negative regulation of apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045787	positive regulation of cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048752	semicircular canal morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0060005	vestibular reflex
GO:2000108	positive regulation of leukocyte apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003072 Orphan nuclear receptor, NOR1 type
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01284
PR01286
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt