InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPG20

Summary

InnateDB Protein

IDBP-810748.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPG20

Protein Name

spastic paraplegia 20 (Troyer syndrome)

Synonyms

SPARTIN; TAHCCP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000473599

InnateDB Gene

IDBG-24395 (SPG20)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0008219	cell death
GO:0009838	abscission
GO:0051301	cell division
GO:0051881	regulation of mitochondrial membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005886	plasma membrane
GO:0030496	midbody

Protein Structure and Domains

PDB ID

InterPro

IPR007330 MIT
IPR009686 Senescence/spartin-associated

PFAM

PF04212
PF06911

PRINTS

PIRSF

SMART

SM00745

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8N0X7

PhosphoSite

PhosphoSite-Q8N0X7

TrEMBL

A0A024RDV9

UniProt Splice Variant

Entrez Gene

23111

UniGene

RefSeq

NP_001135768

HUGO

HGNC:18514

OMIM

607111

CCDS

CCDS9356

HPRD

IMGT

EMBL

AB011182 AL139377 AY038359 AY038934 AY123329 AY123331 AY123332 AY123333 AY123334 AY123335 AY123336 AY123337 BC047083 CH471075

GenPept

AAH47083 AAK71883 AAK72374 AAM76671 AAM76672 BAA25536 CAC17479 EAX08558 EAX08559 EAX08560 EAX08562