Version 5.4
Homo sapiens Protein: RNF25
Summary
InnateDB Protein IDBP-81106.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF25
Protein Name ring finger protein 25
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295704
InnateDB Gene IDBG-81104 (RNF25)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B. {ECO:0000250, ECO:0000269PubMed:12748188}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0051059 NF-kappaB binding
Biological Process
GO:0016567 protein ubiquitination
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR006575 RWD domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF13639
PF14634
PF05773
PRINTS
PIRSF
SMART SM00184
SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BH1
PhosphoSite PhosphoSite-Q96BH1
TrEMBL
UniProt Splice Variant
Entrez Gene 64320
UniGene Hs.471403
RefSeq NP_071898
HUGO HGNC:14662
OMIM
CCDS CCDS2420
HPRD 09737
IMGT
EMBL AC009974 AK023968 AK222525 AK289501 BC015612 CH471063
GenPept AAH15612 BAB14743 BAD96245 BAF82190 EAW70645

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca