InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HCRTR2

Summary

InnateDB Protein

IDBP-811151.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCRTR2

Protein Name

hypocretin (orexin) receptor 2

Synonyms

OX2R;

Species

Homo sapiens

Ensembl Protein

ENSP00000477548

InnateDB Gene

IDBG-91152 (HCRTR2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008188	neuropeptide receptor activity
GO:0016499	orexin receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior
GO:0022410	circadian sleep/wake cycle process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000204 Orexin receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR004060 Orexin receptor 2
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF03827
PF10320

PRINTS

PR01064
PR00237
PR01012
PR01522

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite