Version 5.4
Homo sapiens Protein: SPAST
Summary
InnateDB Protein IDBP-811320.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAST
Protein Name spastin
Synonyms ADPSP; FSP2; SPG4;
Species Homo sapiens
Ensembl Protein ENSP00000482496
InnateDB Gene IDBG-43191 (SPAST)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008568 microtubule-severing ATPase activity
GO:0009378 four-way junction helicase activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR007330 MIT
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR017179 Spastin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00004
PF07724
PF13304
PF04212
PF05496
PRINTS
PIRSF PIRSF037338
SMART SM00382
SM00745
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 6683
UniGene
RefSeq
HUGO HGNC:11233
OMIM 604277
CCDS
HPRD
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca