InnateDB Protein
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IDBP-81138.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UGCG
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Protein Name
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UDP-glucose ceramide glucosyltransferase
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Synonyms
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GCS; GLCT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000363397
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InnateDB Gene
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IDBG-81136 (UGCG)
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Protein Structure
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Function |
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". {ECO:0000269PubMed:8643456}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Found in all tissues examined. {ECO:0000269PubMed:8643456}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008120
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ceramide glucosyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001173
Glycosyltransferase 2-like
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF00535
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16739
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PhosphoSite |
PhosphoSite-Q16739
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TrEMBL |
A0A024R157
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UniProt Splice Variant |
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Entrez Gene |
7357
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UniGene |
Hs.710686
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RefSeq |
NP_003349
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HUGO |
HGNC:12524
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OMIM |
602874
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CCDS |
CCDS6782
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HPRD |
04190
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IMGT |
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EMBL |
AK314847
AL442066
BC038711
CH471105
D50840
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GenPept |
AAH38711
BAA09451
BAG37364
CAI15902
EAW59091
EAW59092
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