InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP1B1

Summary

InnateDB Protein

IDBP-811632.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP1B1

Protein Name

cytochrome P450, family 1, subfamily B, polypeptide 1

Synonyms

CP1B; CYPIB1; GLC3A; P4501B1;

Species

Homo sapiens

Ensembl Protein

ENSP00000478561

InnateDB Gene

IDBG-46038 (CYP1B1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0001525	angiogenesis
GO:0002930	trabecular meshwork development
GO:0006725	cellular aromatic compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007155	cell adhesion
GO:0007601	visual perception
GO:0008202	steroid metabolic process
GO:0008210	estrogen metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009404	toxin metabolic process
GO:0009636	response to toxic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0016125	sterol metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0030199	collagen fibril organization
GO:0030336	negative regulation of cell migration
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043542	endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045766	positive regulation of angiogenesis
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046466	membrane lipid catabolic process
GO:0048514	blood vessel morphogenesis
GO:0055114	oxidation-reduction process
GO:0061298	retina vasculature development in camera-type eye
GO:0061304	retinal blood vessel morphogenesis
GO:0070301	cellular response to hydrogen peroxide
GO:0071407	cellular response to organic cyclic compound
GO:0071603	endothelial cell-cell adhesion
GO:0097267	omega-hydroxylase P450 pathway
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization
GO:2000377	regulation of reactive oxygen species metabolic process