InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RYK

Summary

InnateDB Protein

IDBP-811640.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RYK

Protein Name

receptor-like tyrosine kinase

Synonyms

D3S3195; JTK5; JTK5A; RYK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000478721

InnateDB Gene

IDBG-57467 (RYK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0016055	Wnt signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022038	corpus callosum development
GO:0030182	neuron differentiation
GO:0031175	neuron projection development
GO:0048705	skeletal system morphogenesis
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003306 WIF domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF02019

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00469
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt