InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GREM1

Summary

InnateDB Protein

IDBP-812082.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GREM1

Protein Name

gremlin 1, DAN family BMP antagonist

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000478319

InnateDB Gene

IDBG-5193 (GREM1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0016015	morphogen activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0036122	BMP binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002092	positive regulation of receptor internalization
GO:0002689	negative regulation of leukocyte chemotaxis
GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009954	proximal/distal pattern formation
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0030199	collagen fibril organization
GO:0030308	negative regulation of cell growth
GO:0030326	embryonic limb morphogenesis
GO:0030502	negative regulation of bone mineralization
GO:0030514	negative regulation of BMP signaling pathway
GO:0033689	negative regulation of osteoblast proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043542	endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046851	negative regulation of bone remodeling
GO:0048263	determination of dorsal identity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051893	regulation of focal adhesion assembly
GO:0051973	positive regulation of telomerase activity
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676	ureteric bud formation
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090027	negative regulation of monocyte chemotaxis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
GO:0090291	negative regulation of osteoclast proliferation
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155	negative regulation of bone trabecula formation
GO:1900158	negative regulation of bone mineralization involved in bone maturation
GO:2000273	positive regulation of receptor activity
GO:2000727	positive regulation of cardiac muscle cell differentiation